Bicycle Therapeutics

Blocks A & B, Portway Building, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom , London, Greater London
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Business Name: Bicycle Therapeutics plc

Business Headquarter: United Kingdom, Cambridgeshire, Cambridge

Business Category: Biopharmaceutical / Biotechnology

Bicycle Therapeutics plc (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company pioneering a completely new class of synthetic medicines called "Bicycles®." Our mission is to transform the lives of patients with cancer and other debilitating diseases by developing precision-guided therapeutics that combine the high affinity and selectivity of antibodies with the superior tissue penetration and rapid clearance of small molecules. These fully synthetic short peptides are constrained into two loops to stabilize their structural geometry, creating highly robust drug candidates.

Our value proposition is defined by our proprietary phage display screening platform, based on the Nobel Prize-winning work of our co-founder, Sir Greg Winter. In 2026, we are focused on our advanced clinical pipeline, specifically Bicycle Toxin Conjugates (BTCs®) and Bicycle Radioconjugates (BRCs®). Our lead program, zelenectide pevedotin, is currently in registrational trials for metastatic urothelial cancer. Through strategic partnerships with leaders like Novartis, Genentech, and Bayer, we are also exploring the application of Bicycle technology in therapeutic areas beyond oncology, including respiratory and cardiometabolic diseases.

Business Helpdesk Number: 01223261503

Founder Name: Sir Greg Winter and Professor Christian Heinis

Founded Date: 27 October 2017 (Incorporated as PLC); Original founded 2009

Phone Number: 01223261503

Email Address: info@bicycletx.com / IR@bicycletx.com

Website URL: https://www.bicycletherapeutics.com

Physical Address: Blocks A & B, Portway Building, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom

Landmark: Near Granta Park Cricket Ground

Service or Products: Bicycle Toxin Conjugates (BTC®), Bicycle Radioconjugates (BRC®), Bicycle Tumor-Targeted Immune Cell Agonists (TICAs®), Proprietary Phage Display Screening Services.

Amenities: State-of-the-art Laboratory Facilities, Online Investor Resource Center, Transatlantic Operational Hubs (Cambridge, UK & Boston, UK), Clinical Trial Participant Support.

Accepted Payment Methods: Institutional Funding, Research Grants, Public Equity Trading (NASDAQ: BCYC), Milestone-based Collaboration Payments.

Languages Supported: English.

Specialization: Bicyclic Peptides, Precision Oncology, Targeted Radiopharmaceuticals, Drug Conjugate Development.

Certifications: FCA Regulated (UK Entity), NASDAQ Listed (BCYC), GLP/GMP Compliant Research.

Social Media Links: LinkedIn, Twitter/X

Business Registration Number: 11036004

Brand Association Name: Bicycle, Bicycles®, BTC®, BRC®.

Working Hours: Monday–Friday: 09:00 – 17:30; Saturday–Sunday: Closed..

Year Founded: 2009

Service Area Radius: National (United Kingdom and International)

Brands: Bicycles®, BTC®, BRC®, TICA®.

Number of Employees: 250

Associations: Association of the British Pharmaceutical Industry (ABPI), BioIndustry Association (BIA).

FAQs

1. What exactly is a "Bicycle" molecule?
A Bicycle is a short peptide constrained by a chemical scaffold to form two loops. This structure allows the molecule to bind to targets with the high precision of an antibody but with the small size required to penetrate tumors effectively and clear the body quickly.

2. Is the company publicly traded in the UK?
Bicycle Therapeutics plc is incorporated in England and Wales, but its primary listing is on the NASDAQ in the United States under the ticker BCYC.

3. What is the current status of your lead cancer drug?
Our lead candidate, zelenectide pevedotin (formerly BT8009), is currently in a Phase 2/3 registrational trial called Duravelo-2 for patients with metastatic urothelial cancer.

4. Does the company conduct its own manufacturing?
While we lead the R&D and clinical strategy, we utilize a transatlantic supply chain. In 2026, we established key collaborations with the UK National Nuclear Laboratory to secure the supply of isotopes for our radiopharmaceutical pipeline.

5. How can I participate in a clinical trial?
Information regarding our ongoing clinical trials, including eligibility and site locations for the Duravelo studies, can be found in the "Patients" section of our website or via clinicaltrials.gov.

IMPORTANT NOTE: As of March 2026, Bicycle Therapeutics remains at the forefront of the radiopharmaceutical and oncology sectors. Following significant leadership transitions in February 2026—including the appointment of Travis Thompson as CFO and Michael Skynner as CSO—the company has solidified its financial position with a cash runway expected to extend into 2028. This stability supports the pivotal Phase 2/3 Duravelo-2 trial for its lead candidate, zelenectide pevedotin.

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Business summaryBicycle Therapeutics (BCYC) is developing a novel class of precision-guided Bicycles® for cancer and serious diseases. Explore our clinical pipeline and technol
Year of Establishment2009
AssociationsAssociation of the British Pharmaceutical Industry (ABPI), BioIndustry Association (BIA).

Support

Contact the official Bicycle Therapeutics Support Number for fast, reliable assistance in the Business Services industry. The Bicycle Therapeutics customer care team is available to handle inquiries. You can also access the Bicycle Therapeutics official website at www.bicycletherapeutics.com for complete service details. For written queries, use the Bicycle Therapeutics support email. Located at Blocks A & B, Portway Building, Granta Park, Great Abington, Cambridge, CB21 6GS, United Kingdom, London, Greater London United Kingdom.

Reach the Bicycle Therapeutics contact number to connect with verified experts in the Business Services sector. The Bicycle Therapeutics helpline offers quick resolutions and trusted guidance. You can also contact the Bicycle Therapeutics support team through official Bicycle Therapeutics email for professional assistance.